Article Navigation
- < Previous
- Next >
Journal Article
Get access
, Hye Chang Rhim, BA Korea University College of Medicine , Seoul Korea Search for other works by this author on: Oxford Academic Min Seo Kim, BA Korea University College of Medicine , Seoul Korea Search for other works by this author on: Oxford Academic Young-Jin Park, MD Department of Urology Konkuk University Medical Center Konkuk University School of Medicine , Seoul Korea Search for other works by this author on: Oxford Academic Woo Suk Choi, MD Department of Urology Konkuk University Medical Center Konkuk University School of Medicine , Seoul Korea Search for other works by this author on: Oxford Academic Hyoung Keun Park, MD Department of Urology Konkuk University Medical Center Konkuk University School of Medicine , Seoul Korea Search for other works by this author on: Oxford Academic Hyeong Gon Kim, MD Department of Urology Konkuk University Medical Center Konkuk University School of Medicine , Seoul Korea Search for other works by this author on: Oxford Academic Aram Kim, MD Department of Urology Konkuk University Medical Center Konkuk University School of Medicine , Seoul Korea Search for other works by this author on: Oxford Academic Sung Hyun Paick, MD, PhD Department of Urology Konkuk University Medical Center Konkuk University School of Medicine , Seoul Korea Corresponding Author: Sung Hyun Paick, MD, PhD, Department of Urology, Konkuk University Medical Center, Konkuk University School of Medicine, 120-2, Neungdong-ro, Gwangjin-gu, Seoul 05030, Korea. Tel: 82-2-2030-7673; Fax: 82-2-2030-7748. 20030010@kuh.ac.kr. Search for other works by this author on: Oxford Academic
The Journal of Sexual Medicine, Volume 16, Issue 2, February 2019, Pages 223–234, https://doi.org/10.1016/j.jsxm.2018.12.002
Published:
01 February 2019
Article history
Received:
26 July 2018
Accepted:
06 December 2018
Published:
01 February 2019
A correction has been published: The Journal of Sexual Medicine, Volume 17, Issue 3, March 2020, Page 560, https://doi.org/10.1016/j.jsxm.2020.01.021
- Views
- Article contents
- Figures & tables
- Video
- Audio
- Supplementary Data
-
Cite
Cite
Hye Chang Rhim, Min Seo Kim, Young-Jin Park, Woo Suk Choi, Hyoung Keun Park, Hyeong Gon Kim, Aram Kim, Sung Hyun Paick, The Potential Role of Arginine Supplements on Erectile Dysfunction: A Systemic Review and Meta-Analysis, The Journal of Sexual Medicine, Volume 16, Issue 2, February 2019, Pages 223–234, https://doi.org/10.1016/j.jsxm.2018.12.002
Close
Search
Close
Search
Advanced Search
Abstract
Introduction
The efficacy and safety of arginine supplements in erectile dysfunction (ED) remain debatable.
Aim
To assess the potential role of arginine supplements on ED as alternatives to phosphodiesterase inhibitors.
Methods
Studies published up to April 2018 that evaluated the efficacy of arginine supplements were identified from multiple databases (Google Scholar, PubMed, Medline, Embase, Kiss, DBpia, and Cochrane databases). Studies comparing arginine supplements with placebo or no treatment; focusing only on patients with mild to moderate severity of ED; and presenting outcomes such as improvement rate, International Index of Erectile Function (IIEF) score, and adverse effects were included. Subgroup analysis for arginine alone and arginine in combination with other substances was further conducted to increase interpretability.
Main Outcome Measure
The strength of the association between arginine supplements and ED was assessed using relative odds ratios and weighted mean differences with 95% CI.
Results
In total, 10 randomized controlled trials met the inclusion criteria, reporting the outcomes of 540 patients with ED. The analysis demonstrated that arginine supplements with dosage ranging from 1,500 to 5,000 mg significantly improved ED compared with placebo or no treatment (odds ratios, 3.37 [1.29, 8.77], P= .01, I2= 44). Arginine supplements also caused significant improvements in the IIEF subdomain scores of overall satisfaction, intercourse satisfaction, orgasmic function, and erectile function, whereas the IIEF sexual desire score remain unchanged. The adverse effect rate in the arginine-treated group was 8.3%, and that in the placebo group was 2.3%, none of which were severe.
Clinical Implications
Arginine supplements can be recommended to patients with mild to moderate ED.
Strength & Limitations
The strength of this study is that it is the first meta-analysis to assess the potential role of arginine supplements in ED compared with placebo or no treatment. A limitation is that the treatment dosage and duration varied among studies, which may have contributed to study heterogeneity.
Conclusion
The results of our systematic review and meta-analysis provide evidence on the effectiveness of arginine supplements for mild to moderate ED.
Erectile Dysfunction, L-Arginine, Pycnogenol, Yohimbine
© International Society for Sexual Medicine 2018
Issue Section:
Erectile Function > Review
You do not currently have access to this article.
Download all slides
Sign in
Get help with access
Personal account
- Sign in with email/username & password
- Get email alerts
- Save searches
- Purchase content
- Activate your purchase/trial code
- Add your ORCID iD
Sign in Register
Institutional access
- Sign in with a library card
- Sign in with username/password
- Recommend to your librarian
Sign in through your institution
Sign in through your institution
Institutional account management
Sign in as administrator
Get help with access
Institutional access
Access to content on Oxford Academic is often provided through institutional subscriptions and purchases. If you are a member of an institution with an active account, you may be able to access content in one of the following ways:
IP based access
Typically, access is provided across an institutional network to a range of IP addresses. This authentication occurs automatically, and it is not possible to sign out of an IP authenticated account.
Sign in through your institution
Choose this option to get remote access when outside your institution. Shibboleth/Open Athens technology is used to provide single sign-on between your institution’s website and Oxford Academic.
- Click Sign in through your institution.
- Select your institution from the list provided, which will take you to your institution's website to sign in.
- When on the institution site, please use the credentials provided by your institution. Do not use an Oxford Academic personal account.
- Following successful sign in, you will be returned to Oxford Academic.
If your institution is not listed or you cannot sign in to your institution’s website, please contact your librarian or administrator.
Sign in with a library card
Enter your library card number to sign in. If you cannot sign in, please contact your librarian.
Society Members
Society member access to a journal is achieved in one of the following ways:
Sign in through society site
Many societies offer single sign-on between the society website and Oxford Academic. If you see ‘Sign in through society site’ in the sign in pane within a journal:
- Click Sign in through society site.
- When on the society site, please use the credentials provided by that society. Do not use an Oxford Academic personal account.
- Following successful sign in, you will be returned to Oxford Academic.
If you do not have a society account or have forgotten your username or password, please contact your society.
Sign in using a personal account
Some societies use Oxford Academic personal accounts to provide access to their members. See below.
Personal account
A personal account can be used to get email alerts, save searches, purchase content, and activate subscriptions.
Some societies use Oxford Academic personal accounts to provide access to their members.
Viewing your signed in accounts
Click the account icon in the top right to:
- View your signed in personal account and access account management features.
- View the institutional accounts that are providing access.
Signed in but can't access content
Oxford Academic is home to a wide variety of products. The institutional subscription may not cover the content that you are trying to access. If you believe you should have access to that content, please contact your librarian.
Institutional account management
For librarians and administrators, your personal account also provides access to institutional account management. Here you will find options to view and activate subscriptions, manage institutional settings and access options, access usage statistics, and more.
Purchase
Subscription prices and ordering for this journal
Purchasing options for books and journals across Oxford Academic
Short-term Access
To purchase short-term access, please sign in to your personal account above.
Don't already have a personal account? Register
The Potential Role of Arginine Supplements on Erectile Dysfunction: A Systemic Review and Meta-Analysis - 24 Hours access
EUR €39.00
GBP £34.00
USD $42.00
Advertisement
Citations
Views
814
Altmetric
More metrics information
Metrics
Total Views 814
548 Pageviews
266 PDF Downloads
Since 1/1/2023
Month: | Total Views: |
---|---|
January 2023 | 77 |
February 2023 | 228 |
March 2023 | 26 |
April 2023 | 14 |
May 2023 | 36 |
June 2023 | 12 |
July 2023 | 18 |
August 2023 | 24 |
September 2023 | 34 |
October 2023 | 15 |
November 2023 | 21 |
December 2023 | 30 |
January 2024 | 19 |
February 2024 | 12 |
March 2024 | 28 |
April 2024 | 20 |
May 2024 | 30 |
June 2024 | 15 |
July 2024 | 51 |
August 2024 | 21 |
September 2024 | 22 |
October 2024 | 23 |
November 2024 | 37 |
December 2024 | 1 |
Altmetrics
Email alerts
Article activity alert
Advance article alerts
New issue alert
Receive exclusive offers and updates from Oxford Academic
Related articles in
- Web of Science
- Google Scholar
Citing articles via
Google Scholar
-
Latest
-
Most Read
-
Most Cited
More from Oxford Academic
Medicine and Health
Neuroscience
Reproductive Medicine
Science and Mathematics
Books
Journals
Advertisement